Acetaminophen / Doxylamine / Pseudoephedrine
This multi-ingredient medication combines an analgesic, an antihistamine, and a decongestant to provide relief from multiple cold, flu, and allergy symptoms simultaneously. It is typically used by adults and adolescents experiencing congestion, headache, body aches, fever, sneezing, and runny nose. The three active ingredients work together to address both nasal and sinus symptoms along with general aches and discomfort.
A combination cold/flu medication that relieves nasal congestion, allergy symptoms, pain, and fever through three complementary active ingredients.
Key facts at a glance
- RxNorm
- 285036
- Generic
- Acetaminophen / Doxylamine / Pseudoephedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, flu, or hay fever including nasal congestion, sinus congestion and pressure, headache, minor body aches and pains, fever, sneezing, runny nose, and itchy throat.
Acetaminophen reduces fever and relieves minor aches and pains. Doxylamine, an antihistamine, blocks histamine to reduce sneezing, runny nose, and itchy/watery eyes. Pseudoephedrine constricts blood vessels in the nasal passages to reduce swelling and congestion.
May cause drowsiness; avoid alcohol and operating machinery until you know how the medication affects you. Do not use if you have certain conditions including severe hypertension, coronary artery disease, or are taking MAO inhibitors. Consult a healthcare provider before use if you have diabetes, glaucoma, thyroid disorders, or are pregnant/nursing. Do not exceed recommended doses.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy