Acetaminophen / Doxylamine / Salicylamide
This combination medication contains two analgesics (acetaminophen and salicylamide) along with an antihistamine (doxylamine) that has sedative properties. It is typically used for the temporary relief of minor aches, pains, and headaches while also helping to reduce difficulty falling asleep. The sedative component makes it particularly suitable for nighttime use when pain relief and sleep assistance are both needed.
A combination analgesic and sleep aid used for nighttime pain relief.
Key facts at a glance
- RxNorm
- 1008262
- Generic
- Acetaminophen / Doxylamine / Salicylamide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves minor aches and pains associated with headaches, muscle aches, backaches, arthritis, colds, or flu, and helps reduce difficulty falling asleep when pain interferes with rest.
Acetaminophen and salicylamide work by reducing pain signals and lowering fever through their effects on the body's pain and temperature regulation pathways. Doxylamine is an antihistamine that causes drowsiness by blocking histamine receptors in the brain, promoting sleep onset.
May cause drowsiness; avoid alcohol and operating machinery until you know how this medication affects you. Do not exceed recommended doses as acetaminophen overdose can cause serious liver damage. Consult a healthcare provider before use if you have liver disease, glaucoma, enlarged prostate, or breathing problems.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy