Acetaminophen / Ephedrine / Guaifenesin
This combination medication contains three active ingredients that work together to provide relief from multiple symptoms of colds, allergies, and respiratory infections. Acetaminophen reduces pain and fever, while ephedrine acts as a decongestant to relieve nasal stuffiness, and guaifenesin helps loosen and thin mucus in the airways to ease congestion.
A multi-symptom cold and allergy relief medication combining a pain reliever/fever reducer, decongestant, and expectorant.
Key facts at a glance
- RxNorm
- 2178938
- Generic
- Acetaminophen / Ephedrine / Guaifenesin
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, allergies, or respiratory infections including nasal/sinus congestion, chest congestion, minor aches and pains, headache, and fever
Acetaminophen inhibits pain and fever signals in the brain; ephedrine constricts blood vessels in the nasal passages to reduce swelling and congestion; guaifenesin thins and loosens mucus in the airways, making it easier to clear through coughing
Should not be used with other products containing acetaminophen; avoid in patients with certain heart conditions, high blood pressure, thyroid disorders, or glaucoma due to ephedrine component; consult healthcare provider before use if taking other medications or if symptoms persist beyond 7 days
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy