Acetaminophen / Guaifenesin
Acetaminophen/Guaifenesin is a combination medication that addresses multiple symptoms of upper respiratory infections. Acetaminophen relieves pain and reduces fever while guaifenesin helps loosen and thin mucus in the airways to ease congestion. This combination is commonly used for cold, flu, and allergy symptoms that include chest congestion along with aches and fever.
A cold and flu remedy combining a pain reliever/fever reducer with an expectorant to address both respiratory congestion and associated aches and fever.
Key facts at a glance
- RxNorm
- 606096
- Generic
- Acetaminophen / Guaifenesin
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of symptoms associated with colds, flu, and upper respiratory infections including chest congestion, nasal congestion, headache, minor aches and pains, and fever.
Acetaminophen works in the brain to reduce pain signals and lower body temperature, while guaifenesin acts on the respiratory tract to increase fluid secretion and thin mucus, making it easier to cough out.
Should not be used with other acetaminophen-containing products to avoid overdose. Patients with liver disease, chronic alcohol use, or certain other conditions should consult a doctor before use. Adequate fluid intake helps the expectorant work effectively.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy