Acetaminophen / Guaifenesin / Phenylephrine
This combination medication provides relief from multiple cold and flu symptoms. It contains three active ingredients that work together to reduce fever and pain, relieve nasal congestion, and help loosen chest congestion.
A multi-symptom cold and flu relief medication combining a pain reliever/fever reducer, expectorant, and decongestant.
Key facts at a glance
- RxNorm
- 631158
- Generic
- Acetaminophen / Guaifenesin / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, flu, or sinus congestion including headache, fever, body aches, sore throat, nasal congestion, chest congestion, and stuffy nose.
Acetaminophen reduces fever and relieves pain; Guaifenesin helps loosen and thin mucus in the airways to make coughs more productive; Phenylephrine shrinks blood vessels in the nasal passages to reduce swelling and congestion.
Do not use with other acetaminophen products to avoid overdose. Consult a healthcare provider if you have high blood pressure, heart disease, diabetes, thyroid problems, or are pregnant/nursing. Stop use and consult a doctor if symptoms worsen, last more than 7 days, or are accompanied by a fever that persists for more than 3 days.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy