Acetaminophen / Guaifenesin / Pseudoephedrine
This combination medication provides relief from multiple cold and flu symptoms. Acetaminophen reduces fever and pain, while guaifenesin helps loosen and thin mucus in the airways, and pseudoephedrine shrinks swollen nasal passages to relieve congestion. It is commonly used by adults and children experiencing concurrent symptoms of pain, fever, chest congestion, and nasal congestion.
A multi-symptom cold and flu remedy combining a pain reliever/fever reducer, expectorant, and decongestant.
Key facts at a glance
- RxNorm
- 1007269
- Generic
- Acetaminophen / Guaifenesin / Pseudoephedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, flu, or allergies including fever, headache, body aches, sore throat, nasal congestion, sinus congestion, and chest congestion with mucus.
Acetaminophen inhibits pain and fever signals in the brain. Guaifenesin works as an expectorant by thinning and loosening mucus in the airways, making it easier to clear. Pseudoephedrine constricts blood vessels in the nasal passages, reducing swelling and congestion.
Do not exceed recommended dosage as acetaminophen can cause liver damage. Pseudoephedrine may cause insomnia, nervousness, or elevated blood pressure. Consult a doctor before use if pregnant, nursing, or taking other medications. Not recommended for children under certain ages without medical guidance.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy