Acetaminophen / Ibuprofen
Acetaminophen/Ibuprofen is a combination medication that pairs an analgesic and antipyretic (acetaminophen) with a nonsteroidal anti-inflammatory drug (ibuprofen). This combination provides relief for pain and fever by targeting different pathways in the body, offering broader symptom relief than either ingredient alone.
A combination pain reliever and fever reducer that works through dual mechanisms to address mild to moderate pain and fever.
Key facts at a glance
- RxNorm
- 818102
- Generic
- Acetaminophen / Ibuprofen
- Class
- multi-ingredient
- Brands
- Combogesic
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats mild to moderate pain such as headaches, toothaches, muscle aches, and menstrual cramps. Also reduces fever. Often used when single-ingredient pain relievers are insufficient for symptom control.
Acetaminophen works in the brain to raise the pain threshold and reduce fever, while ibuprofen blocks enzymes (COX-1 and COX-2) that produce prostaglandins—chemicals that cause pain, inflammation, and fever. Together, they provide complementary relief.
Should not be used by individuals with certain medical conditions (such as severe kidney or liver disease) or those taking blood thinners. Avoid alcohol while taking this medication. Do not exceed recommended doses or use for extended periods without medical supervision. Not recommended during late pregnancy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy