Acetaminophen / Isometheptene
Acetaminophen/Isometheptene is a combination medication used primarily to treat tension headaches and mild to moderate migraine episodes. The acetaminophen component provides analgesic and fever-reducing effects, while isometheptene acts as a vasoconstrictor to help relieve headache symptoms. This medication is typically prescribed for adult patients experiencing vascular or tension-type headaches.
A combination analgesic and vasoconstrictor used to relieve tension and migraine headaches in adults.
Key facts at a glance
- RxNorm
- 687408
- Generic
- Acetaminophen / Isometheptene
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of tension headaches and mild to moderate migraine episodes in adults. May also be used for other acute headache types as determined by a healthcare provider.
Acetaminophen works by inhibiting prostaglandin synthesis in the central nervous system to reduce pain perception. Isometheptene acts as a mild sympathomimetic vasoconstrictor, helping to narrow blood vessels in the brain to address vascular components of headache.
Should not be used by patients with severe hypertension, heart disease, glaucoma, or those taking MAO inhibitors. Avoid alcohol during treatment as it may increase liver toxicity risk from acetaminophen. Do not exceed recommended dosing; overuse may lead to medication-overuse headaches. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy