Acetaminophen / Melatonin
This combination medication pairs the pain-relieving and fever-reducing properties of acetaminophen with the sleep-regulating effects of melatonin. It is designed for individuals experiencing mild to moderate pain (such as headaches, muscle aches, or menstrual discomfort) who also have difficulty falling asleep. The melatonin component helps promote drowsiness while acetaminophen addresses the underlying pain that may be interfering with rest.
A nighttime pain reliever combined with a sleep aid for people dealing with pain that disrupts their sleep.
Key facts at a glance
- RxNorm
- 820463
- Generic
- Acetaminophen / Melatonin
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves minor aches and pains (headache, muscle aches, backache, toothache) and reduces fever while also helping to facilitate sleep onset for occasional sleeplessness.
Acetaminophen works by inhibiting prostaglandin synthesis in the central nervous system to reduce pain and fever. Melatonin is a hormone produced by the pineal gland that regulates the sleep-wake cycle; supplemental melatonin helps signal the body that it is time to sleep.
Should not be used with alcohol or other acetaminophen-containing products to avoid liver toxicity. Consult a healthcare provider before use if pregnant, breastfeeding, taking other medications, or if sleep problems persist beyond 2 weeks. Not intended for long-term daily use without medical supervision.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy