Acetaminophen / Methionine
Acetaminophen/Methionine combines a common pain reliever and fever reducer with an amino acid that helps protect the liver. Methionine helps replenish glutathione, a natural antioxidant that neutralizes toxic metabolites produced when acetaminophen is metabolized. This combination is primarily used to provide analgesic effects while reducing the risk of liver toxicity associated with acetaminophen use.
A pain and fever reducer combined with a liver-protective agent that helps prevent toxicity.
Key facts at a glance
- RxNorm
- 619676
- Generic
- Acetaminophen / Methionine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of mild to moderate pain and fever, with the methionine component included to reduce the risk of hepatotoxicity from acetaminophen metabolism. May be used in acute overdose management as part of antidote therapy.
Acetaminophen provides analgesic and antipyretic effects through central nervous system action. Methionine serves as a glutathione precursor, replenishing stores that help detoxify NAPQI, a harmful metabolite produced during acetaminophen metabolism.
Should not be used by patients with severe liver disease or those with known hypersensitivity to any components. Alcohol use may increase hepatotoxicity risk. Do not exceed recommended daily doses of acetaminophen. Consult healthcare provider before use during pregnancy or when taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy