Acetaminophen / Orphenadrine
Acetaminophen/Orphenadrine is a combination medication that pairs a pain reliever with a muscle relaxant to address both pain and muscle tension simultaneously. It is primarily used for acute musculoskeletal conditions such as muscle strains, tension headaches, and other painful conditions involving muscle spasms. The two active ingredients work together to provide more comprehensive relief than either component alone.
This combination medication provides pain relief and muscle relaxation for acute musculoskeletal conditions like tension headaches and muscle strains.
Key facts at a glance
- RxNorm
- 814872
- Generic
- Acetaminophen / Orphenadrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats acute musculoskeletal pain conditions including muscle strains, tension headaches, and other painful conditions involving muscle spasms or tension. Typically prescribed for short-term management of pain associated with muscle contraction.
Acetaminophen reduces pain by decreasing prostaglandin production in the brain, while Orphenadrine acts as a muscle relaxant by blocking nerve impulses sent to the brain. Together, they address both the pain sensation and underlying muscle tension.
May cause drowsiness; avoid alcohol and other CNS depressants. Intended for short-term use only (generally 2-3 weeks maximum). Patients with liver disease, glaucoma, or urinary retention should avoid this medication. Do not exceed recommended doses due to risk of acetaminophen-related liver damage.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy