Acetaminophen / Oxycodone
Acetaminophen/Oxycodone is a combination medication used to manage moderate to severe pain when other pain relievers are not effective. It combines a non-opioid analgesic (acetaminophen) with an opioid (oxycodone) to provide more effective pain relief than either component alone. This medication is typically prescribed for short-term use following surgery, injury, or other painful conditions.
A combination opioid analgesic used to treat moderate to severe pain.
Key facts at a glance
- RxNorm
- 214183
- Generic
- Acetaminophen / Oxycodone
- Class
- multi-ingredient
- Brands
- Primlev, Nalocet, Endocet, Prolate, Percocet
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe pain requiring an opioid when non-opioid analgesics alone are insufficient. Commonly prescribed for post-surgical pain, injury-related pain, and other acute painful conditions.
Acetaminophen reduces pain perception and fever through action on the brain's pain and temperature regulation centers. Oxycodone is an opioid agonist that binds to mu-opioid receptors in the central nervous system, altering the perception of and response to pain.
Contains an opioid with risk of dependence, addiction, and respiratory depression. Avoid alcohol and other CNS depressants. Acetaminophen component poses risk of liver damage at high doses. This is a Schedule II controlled substance available only through prescription with strict dosing guidelines. Do not exceed recommended dose to avoid acetaminophen toxicity.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy