Acetaminophen / Pamabrom / Pyrilamine
This medication combines an analgesic, a mild diuretic, and an antihistamine to provide relief from multiple menstrual symptoms. It addresses pain, bloating from fluid retention, and associated discomfort such as irritability and tension. This combination is specifically formulated for premenstrual and menstrual symptom relief.
A combination analgesic, diuretic, and antihistamine used to relieve menstrual symptoms including pain, bloating, and irritability.
Key facts at a glance
- RxNorm
- 214156
- Generic
- Acetaminophen / Pamabrom / Pyrilamine
- Class
- multi-ingredient
- Brands
- Pamprin Multi-Symptom, Premsyn PMS
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of premenstrual syndrome (PMS) and menstrual symptoms including headaches, backaches, muscle aches, cramps, bloating, water retention, and irritability.
Acetaminophen provides pain relief by blocking pain signals in the nervous system. Pamabrom, a mild diuretic, helps reduce fluid retention and bloating. Pyrilamine, an antihistamine, helps relieve tension, irritability, and anxiety associated with hormonal fluctuations.
Do not exceed recommended dosage. Avoid alcohol during use. Those with liver disease should use acetaminophen cautiously. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications. Not intended for regular daily use without medical supervision.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy