Acetaminophen / Pentazocine
Acetaminophen/Pentazocine is a combination analgesic medication used to manage moderate to moderately severe pain. Acetaminophen provides pain relief and fever reduction through COX enzyme inhibition, while pentazocine acts as a partial opioid agonist at mu receptors to enhance pain control. This combination is typically prescribed when non-opioid analgesics alone are insufficient for pain management.
A combination pain medication pairing an opioid partial agonist with acetaminophen for moderate to severe pain relief.
Key facts at a glance
- RxNorm
- 214185
- Generic
- Acetaminophen / Pentazocine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Management of moderate to moderately severe pain where other non-opioid analgesics are inadequate. May be used for acute pain following surgery, injury, or other conditions requiring opioid-level pain control.
Pentazocine acts as a partial agonist at mu opioid receptors in the brain, reducing pain perception. Acetaminophen works peripherally and centrally by inhibiting cyclooxygenase enzymes and activating serotonergic pathways, providing additional analgesia and fever reduction.
Contains an opioid component (pentazocine), so carries risks of dependence, tolerance, and withdrawal with prolonged use. Should be used at the lowest effective dose for shortest duration. Avoid alcohol and other CNS depressants. Monitor liver function due to acetaminophen component. Not recommended for use in patients with head injuries, respiratory depression, or porphyria.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy