Acetaminophen / Pheniramine / Phenylephrine
This combination medication provides relief from multiple symptoms of the common cold, allergies, and sinus congestion. Acetaminophen reduces fever and pain, pheniramine works as an antihistamine to address sneezing and runny nose, while phenylephrine acts as a decongestant to relieve nasal congestion.
A multi-symptom cold and allergy relief medication combining a pain reliever, antihistamine, and decongestant.
Key facts at a glance
- RxNorm
- 617772
- Generic
- Acetaminophen / Pheniramine / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for temporary relief of symptoms associated with the common cold, influenza, hay fever, and other upper respiratory allergies including headache, fever, body aches, nasal congestion, sneezing, runny nose, and itchy or watery eyes.
Acetaminophen inhibits prostaglandin synthesis in the central nervous system to reduce pain and fever. Pheniramine blocks histamine H1 receptors to prevent allergic symptoms. Phenylephrine stimulates alpha-adrenergic receptors in nasal blood vessels, causing vasoconstriction that reduces nasal swelling and congestion.
This medication should not be used with other products containing acetaminophen to avoid overdose. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications. Do not use if you have certain medical conditions such as high blood pressure, heart disease, or glaucoma without medical supervision.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy