Acetaminophen / Phenobarbital
This combination medication pairs acetaminophen, a widely used analgesic and fever reducer, with phenobarbital, a barbiturate sedative. It is typically prescribed for managing pain accompanied by anxiety, tension, or restlessness, where the calming effects of phenobarbital complement the pain-relieving properties of acetaminophen.
An analgesic-sedative combination for treating pain when anxiety or tension is also present.
Key facts at a glance
- RxNorm
- 689794
- Generic
- Acetaminophen / Phenobarbital
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Management of mild to moderate pain associated with anxiety, tension, or restlessness. May be used for tension-type headaches or other painful conditions where sedation provides additional therapeutic benefit.
Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system. Phenobarbital enhances the effects of GABA, an inhibitory neurotransmitter, producing sedative, anxiolytic, and muscle relaxant effects that complement the analgesic component.
Use only as prescribed due to risk of dependence with phenobarbital. Avoid alcohol and other CNS depressants. May cause drowsiness; do not drive until you know how it affects you. Not recommended during pregnancy or in patients with certain respiratory conditions. Long-term use requires medical supervision.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy