Acetaminophen / Phenylephrine
Acetaminophen/Phenylephrine is a combination medication used to temporarily relieve multiple symptoms associated with colds, allergies, and sinus congestion. It contains acetaminophen for pain and fever relief, while phenylephrine acts as a nasal decongestant to reduce stuffiness.
A cold and allergy relief medication combining a pain reliever/fever reducer with a nasal decongestant.
Key facts at a glance
- RxNorm
- 214186
- Generic
- Acetaminophen / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves headache, minor aches and pains, fever, nasal congestion, and sinus pressure due to colds, allergies, or hay fever.
Acetaminophen works in the brain to reduce pain signals and lower body temperature. Phenylephrine is a topical decongestant that constricts blood vessels in the nasal passages, reducing swelling and congestion.
Do not exceed recommended dosage; taking too much acetaminophen may cause serious liver damage. This medication may interact with blood pressure medications, particularly MAO inhibitors and beta-blockers. Consult a doctor before use if you have heart disease, high blood pressure, thyroid problems, diabetes, or are pregnant/nursing.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy