Acetaminophen / Phenylephrine / Pyrilamine
This multi-symptom cold and allergy medication combines three active ingredients to provide relief from multiple symptoms. Acetaminophen reduces fever and pain, phenylephrine shrinks nasal passages to relieve congestion, and pyrilamine works as an antihistamine to address sneezing, runny nose, and itchy or watery eyes. This combination is commonly found in over-the-counter products marketed for cold, flu, and allergy relief.
A combination cold/allergy medication that relieves fever, pain, nasal congestion, and allergy symptoms like sneezing and runny nose.
Key facts at a glance
- RxNorm
- 1241828
- Generic
- Acetaminophen / Phenylephrine / Pyrilamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of common cold, flu, and allergy symptoms including fever, headache, body aches, nasal congestion, sneezing, runny nose, and itchy or watery eyes.
Acetaminophen inhibits prostaglandin production in the brain to reduce fever and pain. Phenylephrine constricts blood vessels in the nasal passages to reduce swelling and congestion. Pyrilamine blocks histamine H1 receptors to prevent allergic symptoms.
Should not be combined with other products containing acetaminophen to avoid overdose risk. May cause drowsiness; avoid operating machinery until you know how it affects you. Consult a healthcare provider before use if you have high blood pressure, heart disease, thyroid disorders, diabetes, glaucoma, or urinary problems. Not recommended during pregnancy without medical advice.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy