Acetaminophen / Phenylpropanolamine / Phenyltoloxamine
This combination medication is used to temporarily relieve symptoms associated with colds, allergies, and sinus conditions. It contains three active ingredients that work together to reduce fever, relieve pain, alleviate nasal congestion, and address allergic symptoms. This medication was previously available in over-the-counter cold and allergy products.
A multi-symptom cold and allergy relief medication combining a pain reliever/fever reducer with a decongestant and antihistamine.
Key facts at a glance
- RxNorm
- 689797
- Generic
- Acetaminophen / Phenylpropanolamine / Phenyltoloxamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves nasal and sinus congestion, sinus pressure, headache, body aches, minor aches and pains, fever, runny nose, and sneezing associated with the common cold, hay fever, or other upper respiratory allergies.
Acetaminophen reduces fever and relieves minor pain. Phenylpropanolamine is a sympathomimetic (alpha-adrenergic agonist) that constricts blood vessels in the nasal passages to reduce swelling and congestion. Phenyltoloxamine is an antihistamine (H1 receptor antagonist) that blocks allergic symptoms such as sneezing, itching, and runny nose.
Phenylpropanolamine was withdrawn from the U.S. market in 2000 due to associated risk of hemorrhagic stroke. This medication may cause drowsiness. Do not exceed recommended doses. Avoid alcohol. Consult a healthcare provider before use if you have hypertension, heart disease, thyroid problems, diabetes, glaucoma, or urinary problems. Not recommended for children under 6 without medical advice.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy