Acetaminophen Piroxicam
Acetaminophen/Piroxicam is a combination medication that pairs an analgesic with a nonsteroidal anti-inflammatory drug (NSAID) to provide pain relief and reduce inflammation. This combination is typically used when single-ingredient therapy is insufficient for managing moderate pain or inflammatory conditions.
A combination analgesic-NSAID medication for treating pain and inflammation when single-ingredient treatments are inadequate.
Key facts at a glance
- RxNorm
- 818190
- Generic
- Acetaminophen / Piroxicam
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This medication is used to treat various painful and inflammatory conditions such as osteoarthritis, rheumatoid arthritis, musculoskeletal disorders, and other conditions requiring both analgesic and anti-inflammatory effects. The combination may be particularly useful when inflammation contributes significantly to the pain being treated.
Acetaminophen works primarily in the central nervous system to reduce pain perception and fever, while piroxicam inhibits cyclooxygenase (COX) enzymes, blocking the production of prostaglandins that cause pain, swelling, and inflammation. The combination provides complementary mechanisms for more comprehensive pain relief.
This medication carries NSAID-related risks including gastrointestinal bleeding, cardiovascular events, and kidney impairment. Patients should avoid alcohol during treatment due to increased liver risk from acetaminophen. It should not be combined with other NSAIDs or used in patients with certain conditions without medical supervision. Always use the lowest effective dose for the shortest duration possible.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy