Acetaminophen Promethazine
Acetaminophen/Promethazine is a combination medication that pairs an analgesic-antipyretic with an antihistamine to address multiple symptoms simultaneously. This combination is typically prescribed for conditions requiring both pain/fever management and relief from nausea, vomiting, or allergic symptoms.
A combination analgesic-antihistamine used for pain, fever, and nausea relief.
Key facts at a glance
- RxNorm
- 814486
- Generic
- Acetaminophen / Promethazine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of mild to moderate pain and fever, particularly when accompanied by nausea, vomiting, or allergic reactions. Often used for post-operative care, migraines, or viral illnesses with multiple symptoms.
Acetaminophen works in the brain to reduce pain signals and lower body temperature, while promethazine blocks histamine receptors and has sedative and anti-nausea effects.
May cause drowsiness; avoid alcohol and operating machinery. Not recommended for children under 2 years old. Should not exceed maximum daily acetaminophen dose to prevent liver damage. Inform your doctor of all current medications due to potential interactions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy