Acetaminophen Propoxyphene
Acetaminophen/Propoxyphene was a combination analgesic used to treat mild to moderate pain. Acetaminophen provided analgesic and fever-reducing effects, while propoxyphene acted as a weak opioid to enhance pain relief. This medication has been withdrawn from markets in multiple countries due to safety concerns.
A combination pain reliever containing acetaminophen and an opioid component, now largely discontinued due to cardiac safety concerns.
Key facts at a glance
- RxNorm
- 639194
- Generic
- Acetaminophen / Propoxyphene
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Previously prescribed for mild to moderate pain relief, such as headaches, muscle aches, menstrual pain, and following minor surgical procedures.
Acetaminophen works centrally to reduce pain perception and fever, while propoxyphene binds to opioid receptors in the brain to provide additional analgesic effects.
This medication has been withdrawn from the US market and many other countries due to cardiac risks (serious arrhythmias) associated with propoxyphene. Other safety concerns included addiction potential, respiratory depression at high doses, and liver toxicity from acetaminophen when exceeding recommended doses. Patients should consult their healthcare provider for safer pain management alternatives.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy