Acetaminophen Pseudoephedrine
Acetaminophen/Pseudoephedrine is a combination medication that provides relief from symptoms associated with colds, allergies, and sinus congestion. Acetaminophen acts as a pain reliever and fever reducer, while pseudoephedrine works as a decongestant to alleviate nasal stuffiness and sinus pressure. This medication is commonly used by adults and children seeking relief from multiple cold or flu symptoms simultaneously.
A combination cold and allergy medication that relieves pain, fever, and nasal congestion.
Key facts at a glance
- RxNorm
- 214187
- Generic
- Acetaminophen / Pseudoephedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for temporary relief of symptoms associated with the common cold, flu, allergies, or other respiratory illnesses, including headache, fever, body aches, nasal congestion, and sinus pressure or congestion.
Acetaminophen reduces pain and fever by affecting the brain's temperature regulation and pain perception centers. Pseudoephedrine is a decongestant that works by constricting blood vessels in the nasal passages and sinuses, reducing swelling and congestion.
Should not be used with alcohol or other acetaminophen-containing products to avoid liver damage. Individuals with hypertension, heart disease, thyroid disorders, or glaucoma should consult a healthcare provider before use. Pseudoephedrine availability may be restricted in some regions due to its use in methamphetamine production. Do not crush or chew extended-release tablets.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy