Acetaminophen Pyrilamine
Acetaminophen/Pyrilamine is a combination medication primarily used for relief of menstrual symptoms. Acetaminophen provides pain relief and reduces fever, while pyrilamine, an antihistamine, helps alleviate anxiety, tension, and nausea commonly associated with menstrual cycles. This combination is commonly found in products marketed for premenstrual syndrome (PMS) and menstrual discomfort.
A multi-ingredient medication combining a pain reliever with an antihistamine to address cramps, headache, bloating, and related menstrual symptoms.
Key facts at a glance
- RxNorm
- 820354
- Generic
- Acetaminophen / Pyrilamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Relief of premenstrual syndrome (PMS) and menstrual symptoms including cramps, headache, backache, bloating, and associated discomfort
Acetaminophen inhibits pain signals and reduces fever centrally, while pyrilamine blocks histamine receptors to reduce anxiety, tension, and nausea associated with menstrual cycles
May cause drowsiness; avoid alcohol; do not exceed recommended acetaminophen dose to prevent liver damage; consult healthcare provider before use if pregnant, nursing, or taking other medications; not intended for prolonged daily use without medical supervision
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy