Acetaminophen Tramadol
Acetaminophen/Tramadol is a combination medication that pairs an analgesic and antipyretic (acetaminophen) with an opioid analgesic (tramadol) to treat moderate to moderately severe pain. The two agents work synergistically to provide more effective pain relief than either component alone. This medication is typically prescribed when other pain relievers, such as NSAIDs or single-agent analgesics, have proven insufficient.
A combination opioid-analgesic medication used to treat moderate to severe pain when other treatments are inadequate.
Key facts at a glance
- RxNorm
- 352362
- Generic
- Acetaminophen / Tramadol
- Class
- multi-ingredient
- Brands
- Ultracet
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute pain severe enough to require an opioid analgesic, such as postoperative pain, injury-related pain, or pain following dental procedures.
Acetaminophen inhibits prostaglandin synthesis in the central nervous system, reducing pain perception and fever. Tramadol binds to mu-opioid receptors and inhibits the reuptake of serotonin and norepinephrine, modulating pain signals. Together, they provide complementary analgesic effects.
Carries risks of liver toxicity (primarily from acetaminophen), respiratory depression, addiction, dependence, and withdrawal symptoms (from tramadol). May increase seizure risk, especially at higher doses. Contraindicated with MAOIs, alcohol, and in patients with respiratory depression or uncontrolled epilepsy. Should not exceed maximum daily acetaminophen dose to avoid liver damage.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy