Acetanilide Aspirin Caffeine Ephedrine
This multi-ingredient medication combines pain-relieving, fever-reducing, stimulant, and decongestant properties to treat symptoms associated with colds, flu, and mild to moderate pain. It is typically used by adults seeking relief from headache, body aches, nasal congestion, and fever. The combination targets multiple symptom pathways simultaneously for more comprehensive relief.
A combination analgesic/decongestant for treating cold and flu symptoms including pain, fever, and nasal congestion.
Key facts at a glance
- RxNorm
- 816812
- Generic
- Acetanilide / Aspirin / Caffeine / Ephedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of headache, muscle pain, toothache, menstrual cramps, fever, and nasal/sinus congestion associated with colds and flu. May also be used for mild respiratory conditions where bronchodilation is beneficial.
Aspirin inhibits cyclooxygenase enzymes to reduce pain and inflammation; caffeine enhances analgesic effectiveness and provides mild stimulation; ephedrine acts as a sympathomimetic to constrict blood vessels and dilate airways, reducing congestion; acetanilide provides additional analgesic and fever-reducing effects through metabolic conversion.
Not recommended for children or teenagers with viral illness due to Reye's syndrome risk from aspirin. Should be avoided by those with aspirin allergy, bleeding disorders, or recent GI bleeding. Ephedrine component may cause insomnia, anxiety, or elevated blood pressure. Avoid use with alcohol, other NSAIDs, or monoamine oxidase inhibitors. Consult healthcare provider before use if pregnant, breastfeeding, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy