Acyclovir Hydrocortisone
Acyclovir/Hydrocortisone is a topical combination medication containing an antiviral agent and a mild corticosteroid. It is primarily used to treat herpes labialis (cold sores) on the lips and face in adults and adolescents. The medication is applied directly to the affected area and is most effective when used at the first sign of a cold sore outbreak.
A topical combination medication used to treat cold sores by combining antiviral and anti-inflammatory properties.
Key facts at a glance
- RxNorm
- 1007804
- Generic
- Acyclovir / Hydrocortisone
- Class
- multi-ingredient
- Brands
- Xerese
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of recurrent herpes labialis (cold sores) on the lips and face in immunocompetent adults and children 6 years of age and older. It is not intended for use in treating genital herpes or other viral infections.
Acyclovir is an antiviral agent that inhibits the replication of the herpes simplex virus, helping to reduce viral activity. Hydrocortisone is a mild corticosteroid that reduces inflammation, swelling, and redness associated with cold sores, potentially promoting faster healing and improving cosmetic outcomes.
For external use only on the lips and area around the mouth. Apply at the first sign of symptoms (tingling, redness, itching) for best results. Do not apply inside the mouth, eyes, or vagina. Wash hands before and after application. Complete the full course of treatment as directed by your healthcare provider. Inform your doctor if symptoms do not improve within 2 weeks.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy