Acyclovir Lidocaine
Acyclovir/Lidocaine is a topical combination medication used to treat herpes simplex virus (HSV) infections, such as cold sores. Acyclovir works as an antiviral to inhibit viral replication, while lidocaine provides localized pain and discomfort relief. This combination is particularly useful for oral herpes (fever blisters) outbreaks.
Topical antiviral-anesthetic combination for treating herpes simplex infections with pain relief.
Key facts at a glance
- RxNorm
- 1250666
- Generic
- Acyclovir / Lidocaine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of herpes simplex virus (HSV) infections, primarily cold sores (herpes labialis) on the lips and face. May also be used for genital herpes lesions when applied topically.
Acyclovir is a nucleoside analog that inhibits viral DNA polymerase, preventing the herpes virus from replicating. Lidocaine is a local anesthetic that blocks sodium channels in nerve endings, temporarily relieving pain, burning, and itching at the affected area.
For external use only; avoid contact with eyes and mucous membranes. Apply at the first sign of outbreak for best results. Wash hands before and after application. Not recommended for prolonged use beyond labeled instructions. Consult a healthcare provider if symptoms worsen or do not improve within 7-10 days.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy