Adapalene Benzoyl Peroxide
Adapalene/Benzoyl Peroxide is a topical combination medication used to treat acne vulgaris. It combines a retinoid (adapalene) with an antibacterial agent (benzoyl peroxide) to target multiple causes of acne including clogged pores, excess oil, and bacterial growth.
A topical acne treatment combining a retinoid and antibacterial agent for multi-targeted acne control.
Key facts at a glance
- RxNorm
- 859393
- Generic
- Adapalene / Benzoyl Peroxide
- Class
- multi-ingredient
- Brands
- Differin Epiduo, Epiduo
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Adapalene/Benzoyl Peroxide is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older. It is effective for treating inflammatory papules, pustules, and comedonal acne.
Adapalene normalizes skin cell turnover and prevents follicular clogging, while benzoyl peroxide reduces Cutibacterium acnes bacteria through its antibacterial properties and helps peel the skin. Together they provide complementary mechanisms for clearer skin.
May cause skin irritation, dryness, and peeling especially during initial weeks. Avoid sun exposure and use sunscreen. Avoid contact with hair, fabric, and colored surfaces as benzoyl peroxide can bleach materials. Not recommended during pregnancy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy