Adiphenine Phenobarbital
This combination medication pairs an antispasmodic agent with a barbiturate sedative. Adiphenine helps relax smooth muscles in the digestive tract, while phenobarbital provides calming effects. This combination is typically used for conditions involving gastrointestinal spasms accompanied by anxiety or tension.
An antispasmodic-sedative combination used for GI spasms with associated anxiety.
Key facts at a glance
- RxNorm
- 1008360
- Generic
- Adiphenine / Phenobarbital
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for gastrointestinal disorders characterized by smooth muscle spasms, such as irritable bowel syndrome, intestinal colic, and conditions with associated anxiety or nervous tension. May also be used for other smooth muscle spasm-related conditions as determined by a healthcare provider.
Adiphenine acts as an anticholinergic antispasmodic, blocking acetylcholine receptors to relax smooth muscle in the GI tract. Phenobarbital is a barbiturate that produces sedation and anxiolytic effects by enhancing GABA activity in the central nervous system. Together, they address both the physical spasm and associated anxiety.
May cause drowsiness or dizziness; avoid alcohol and operating machinery until effects are known. Risk of dependence with phenobarbital component with prolonged use. Not recommended during pregnancy, breastfeeding, or for patients with certain respiratory conditions. Complete medical history and current medication review with a healthcare provider is essential before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy