Afoxolaner Moxidectin Pyrantel
This is a broad-spectrum veterinary parasiticide combining three active ingredients for comprehensive protection in dogs. It addresses both internal parasites (heartworm, intestinal worms) and external parasites (fleas, ticks). The combination provides a convenient monthly preventive and treatment option for multiple parasitic infections.
A triple-action canine parasiticide preventing and treating fleas, ticks, heartworm, and intestinal worms in a single monthly medication.
Key facts at a glance
- RxNorm
- 2642679
- Generic
- Afoxolaner / Moxidectin / Pyrantel
- Class
- multi-ingredient
- Brands
- NexGard Plus
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention and treatment of flea infestations (Ctenocephalides spp.), tick infestations (ixodid ticks), heartworm disease (Dirofilaria immitis), and treatment of intestinal nematode infections including roundworms (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala).
Afoxolaner is an isoxazoline that blocks ligand-gated chloride channels in insect and arachnid nervous systems, causing hyperexcitation and death of fleas and ticks. Moxidectin is a macrocyclic lactone that binds to glutamate-gated chloride channels in parasites, opening them and causing paralysis and death of nematode larvae. Pyrantel is a cholinergic agonist that causes spastic paralysis of susceptible intestinal worms by depolarizing their neuromuscular junctions.
For veterinary use only in dogs. Not for use in cats or other species. Should be given with food for optimal absorption. Heartworm testing is recommended before initiating therapy in endemic areas. Use with caution in puppies under 8 weeks or dogs weighing less than 2 kg. Potential side effects include vomiting, diarrhea, lethargy, and in rare cases, neurologic effects. Afoxolaner belongs to the isoxazoline class which has been associated with rare neurologic adverse reactions. This medication does not protect against Dipylidium caninum or Echinococcus species.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy