Alatrofloxacin Mesylate
Alatrofloxacin Mesylate was an intravenous fluoroquinolone antibiotic used to treat serious bacterial infections. It was withdrawn from the market in 1999 due to rare but severe cases of liver toxicity leading to liver failure and death. This medication required careful monitoring of liver function during treatment.
Alatrofloxacin Mesylate was a fluoroquinolone antibiotic that was discontinued due to serious liver toxicity risks.
Key facts at a glance
- RxNorm
- 221054
- Generic
- Alatrofloxacin Mesylate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Alatrofloxacin was indicated for serious bacterial infections including hospital-acquired pneumonia, intra-abdominal infections, and skin infections when other antibiotics were not appropriate.
As a fluoroquinolone, it worked by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, and repair.
This medication was withdrawn from the market in 1999 due to post-marketing reports of severe hepatotoxicity including liver failure requiring transplantation. Liver function tests were required during treatment. It was contraindicated in patients with known liver disease.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy