Alendronate Sodium
Alendronate Sodium is a bisphosphonate medication primarily used to treat and prevent osteoporosis in postmenopausal women, as well as to manage Paget's disease of bone. It works by inhibiting osteoclasts, the cells responsible for breaking down bone tissue, which helps increase bone density and reduce the risk of fractures.
A bisphosphonate that strengthens bones by preventing bone breakdown, used mainly for osteoporosis and Paget's disease.
Key facts at a glance
- RxNorm
- 203152
- Generic
- Alendronate Sodium
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of osteoporosis in postmenopausal women, treatment of Paget's disease of bone, and management of osteoporosis caused by long-term corticosteroid use in men and women.
Belongs to the bisphosphonate class of drugs; inhibits osteoclast-mediated bone resorption by blocking the enzyme farnesyl pyrophosphate synthase, reducing bone turnover and increasing bone mineral density.
Must be taken first thing in the morning on an empty stomach with plain water only; patient must remain upright (sitting or standing) for at least 30-60 minutes afterward. Common side effects include gastrointestinal irritation, musculoskeletal pain, and rarely osteonecrosis of the jaw or atypical femur fractures with long-term use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy