Aliskiren Amlodipine Hydrochlorothiazide
This medication is a triple-combination antihypertensive product used to treat high blood pressure when single-agent therapy is insufficient. It combines three different blood pressure-lowering mechanisms in one pill, targeting different pathways to achieve better blood pressure control. This combination is typically prescribed for patients with essential hypertension who require multiple medications to reach their target blood pressure.
A three-in-one blood pressure medication combining a direct renin inhibitor, calcium channel blocker, and diuretic for patients needing multiple antihypertensive agents.
Key facts at a glance
- RxNorm
- 1050797
- Generic
- Aliskiren / Amlodipine / Hydrochlorothiazide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of essential hypertension in patients whose blood pressure is not adequately controlled with dual therapy or who may be switched from multiple single-agent medications. This combination is typically reserved for patients requiring three antihypertensive agents for blood pressure management.
Aliskiren is a direct renin inhibitor that blocks the first step of the renin-angiotensin-aldosterone system (RAAS); amlodipine is a calcium channel blocker that relaxes blood vessel muscles; hydrochlorothiazide is a thiazide diuretic that reduces fluid volume by increasing urine output. These three mechanisms work synergistically to lower blood pressure through complementary pathways.
Contraindicated in pregnancy due to potential fetal harm. May cause electrolyte imbalances, particularly hypokalemia with thiazide diuretics. Avoid in patients with anuria, hypersensitivity to sulfonamide derivatives, and those taking ACE inhibitors or ARBs with diabetes. Regular monitoring of kidney function, electrolytes, and blood pressure is essential during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy