Aliskiren Hydrochlorothiazide
Aliskiren/Hydrochlorothiazide is a combination medication used to treat high blood pressure (hypertension) in patients who need multiple agents to achieve adequate blood pressure control. Aliskiren is a direct renin inhibitor that blocks the enzyme responsible for initiating the blood pressure-raising cascade, while hydrochlorothiazide is a thiazide diuretic that helps the kidneys remove excess salt and water from the body.
A combination blood pressure medication pairing a renin inhibitor with a diuretic for patients requiring multi-drug therapy.
Key facts at a glance
- RxNorm
- 802519
- Generic
- Aliskiren / Hydrochlorothiazide
- Class
- multi-ingredient
- Brands
- Tekturna HCT
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of essential hypertension (high blood pressure) in patients not adequately controlled on monotherapy or who are likely to need multiple agents to reach blood pressure goals.
Aliskiren inhibits renin, the enzyme that converts angiotensinogen to angiotensin I, thereby reducing the activity of the renin-angiotensin-aldosterone system. Hydrochlorothiazide promotes sodium and water excretion through the kidneys, decreasing blood volume and cardiac output. Together, they provide complementary blood pressure lowering effects.
Not recommended for use in pregnancy due to potential harm to the fetus. May cause dizziness or dehydration. Should be used with caution in patients with kidney impairment, liver disease, or those taking potassium-sparing diuretics or ACE inhibitors. Regular monitoring of blood pressure, kidney function, and electrolytes is recommended during treatment.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy