Allantoin Diphenhydramine
This topical combination medication pairs an antihistamine with a skin protectant to provide relief from itching and minor skin irritations. Diphenhydramine addresses allergic reactions and itching at the source, while allantoin helps soothe and protect damaged skin. The two ingredients work together to calm irritation and support skin healing.
A topical anti-itch treatment combining an antihistamine with a skin protectant for relieving minor skin irritations and allergic reactions.
Key facts at a glance
- RxNorm
- 1420991
- Generic
- Allantoin / Diphenhydramine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for temporary relief of itching, redness, and irritation caused by minor skin conditions such as insect bites, poison ivy/oak/sumac, eczema, and minor burns or scrapes.
Diphenhydramine blocks histamine receptors in the skin to reduce itching and allergic reactions, while allantoin acts as a skin protectant that helps soothe irritation and maintain skin moisture.
For external use only. Avoid applying to large areas of skin, open wounds, or broken skin. Do not use with other diphenhydramine products. Consult a healthcare provider if symptoms persist beyond 7 days or worsen. May cause drowsiness with extensive application.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy