Allobarbital / Aminopyrine
Allobarbital/Aminopyrine is a historical combination medication that paired a barbiturate sedative with a pyrazolone analgesic-antipyretic. This multi-ingredient product was used for conditions requiring both sedation and moderate pain or fever management. The medication is no longer widely available due to safety concerns associated with its components.
A discontinued combination of a barbiturate sedative and pyrazolone analgesic used for pain and fever with sedation.
Key facts at a glance
- RxNorm
- 1008690
- Generic
- Allobarbital / Aminopyrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This medication was used for moderate pain relief, fever reduction, and sedation, particularly in cases where rest and pain control were both needed. Historically prescribed for headaches, dental pain, and musculoskeletal discomfort with associated anxiety or need for sedation.
Allobarbital acts as a central nervous system depressant by enhancing GABA receptor activity, producing sedation and hypnosis. Aminopyrine works through peripheral mechanisms to reduce pain and fever, though its exact pathway involves inhibition of prostaglandin synthesis and possibly central mechanisms.
Both components of this combination have been largely discontinued in modern practice. Aminopyrine was withdrawn from many markets due to risk of agranulocytosis, and barbiturates carry risks of dependence, tolerance, and respiratory depression. This medication is not recommended for use and has been superseded by safer alternatives.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy