Allopurinol / Probenecid
Allopurinol/Probenecid is a combination medication containing two agents that lower uric acid through complementary mechanisms. It is prescribed for chronic gout and hyperuricemia when single-agent therapy is not adequately controlling uric acid levels. This combination helps reduce gout attacks, dissolve tophi, and prevent uric acid-related kidney complications.
A dual-mechanism uric acid-lowering medication for chronic gout when single agents are insufficient.
Key facts at a glance
- RxNorm
- 815923
- Generic
- Allopurinol / Probenecid
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of chronic gout and hyperuricemia, particularly when monotherapy with either allopurinol or probenecid alone does not provide adequate control. Used to prevent gout attacks, reduce tophi formation, and decrease risk of uric acid kidney stones.
Allopurinol inhibits xanthine oxidase, an enzyme involved in uric acid production, thereby reducing uric acid synthesis. Probenecid increases renal excretion of uric acid by blocking its reabsorption in the kidney tubules. Together, these agents lower serum uric acid through both reduced production and enhanced elimination.
Requires adequate hydration (2-3 liters daily) to reduce kidney stone risk. May initially trigger gout attacks during initiation—prophylactic colchicine is often prescribed. Not recommended in patients with renal impairment, history of kidney stones, or in those with uric acid overproduction. Requires regular monitoring of serum uric acid and renal function.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy