Alogliptin / Pioglitazone
Alogliptin/pioglitazone is a combination medication used to treat type 2 diabetes mellitus in adults when single-agent therapy is insufficient. It combines a DPP-4 inhibitor (alogliptin) with a thiazolidinedione (pioglitazone) to improve glycemic control through complementary mechanisms of action.
A dual-action diabetes medication combining an incretin enhancer and insulin sensitizer for type 2 diabetes management.
Key facts at a glance
- RxNorm
- 1368402
- Generic
- Alogliptin / Pioglitazone
- Class
- multi-ingredient
- Brands
- Oseni
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of type 2 diabetes mellitus in adults when glycemic control is inadequate with diet, exercise, and single-agent therapy. Not indicated for type 1 diabetes or diabetic ketoacidosis.
Alogliptin inhibits the DPP-4 enzyme, increasing insulin release and suppressing glucagon in a glucose-dependent manner. Pioglitazone activates PPAR-gamma receptors, improving insulin sensitivity in adipose, muscle, and liver tissues, reducing hepatic glucose production.
Pioglitazone carries a boxed warning for heart failure risk and may increase bone fracture risk. Avoid in patients with NYHA Class III-IV heart failure. Monitor liver function tests. Not recommended in active liver disease. May cause weight gain and edema. Report any signs of heart failure, liver problems, or unusual bone pain.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy