Althiazide / Spironolactone
A combination diuretic medication pairing a thiazide-like agent with a potassium-sparing diuretic. It is commonly prescribed for managing high blood pressure and conditions involving fluid retention, such as heart failure or liver cirrhosis. The combination works synergistically to remove excess fluid while helping maintain proper potassium balance in the body.
A combination diuretic used to treat high blood pressure and fluid retention while preventing potassium loss.
Key facts at a glance
- RxNorm
- 1008908
- Generic
- Althiazide / Spironolactone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to treat hypertension (high blood pressure), heart failure, and edema (fluid buildup) associated with conditions like liver disease or kidney disorders. May be prescribed when single-agent therapy is insufficient for blood pressure control.
The thiazide-like component (althiazide) works in the kidneys to increase urine production and remove excess salt and water from the body, which helps lower blood pressure. Spironolactone blocks aldosterone hormones, preventing potassium loss and providing additional blood pressure-lowering effects through a different mechanism.
Regular monitoring of kidney function and electrolyte levels (especially potassium) is important during treatment. Patients with kidney disease, high potassium levels, or those taking certain heart medications may need special caution. Common side effects may include dizziness, increased urination, or changes in electrolyte levels.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy