Amdinocillin Pivoxil
Amdinocillin Pivoxil is a penicillin-derived antibiotic prodrug used primarily to treat urinary tract infections. It works by inhibiting bacterial cell wall synthesis and is particularly effective against certain gram-negative bacteria. This medication is typically administered orally and requires conversion to its active form, amdinocillin, in the body.
Amdinocillin Pivoxil is an oral antibiotic used mainly for urinary tract infections that works by attacking bacterial cell walls.
Key facts at a glance
- ATC
- J01CA08
- RxNorm
- 627
- Generic
- Amdinocillin Pivoxil
- Class
- atc-j01
- Brands
- Pivya
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesterno adjustment needed
use only if clearly needed and benefits outweigh potential risks
standard prenatal care
Use with caution and monitor for adverse effects.
pregnancy
second trimesterno adjustment needed
use only if clearly needed and benefits outweigh potential risks
standard prenatal care
Use with caution and monitor for adverse effects.
pregnancy
third trimesterno adjustment needed
use only if clearly needed and benefits outweigh potential risks
standard prenatal care and fetal monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedingno adjustment needed
use with caution; monitor infant for signs of gastrointestinal disturbance
observe infant for diarrhea or candidiasis
Use with caution and monitor for adverse effects.
geriatric
elderlyadjust based on renal function
assess renal function before dosing; reduce dose if creatinine clearance is reduced
monitor renal function regularly
Use with caution and monitor for adverse effects.
pediatric_age
children under 12not recommended
not approved for use in children; contraindicated due to lack of safety data
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
renal_impairment
mild to moderatereduce dose and extend interval
dose reduction recommended; monitor serum drug levels if available
monitor renal function and drug levels
Use with caution and monitor for adverse effects.
renal_impairment
severeuse with extreme caution or avoid
avoid or significantly reduce dose; consider alternative therapy
frequent monitoring of renal function and drug levels
Use of this medication in this population requires careful consideration of risks and benefits.
Statistics and clinical data
Drug class
Antibiotic classification
Common uses
Primary therapeutic indication
Commonly prescribed since
Prescribing history
Mechanism of action
Antibacterial mechanism
Primarily used for uncomplicated urinary tract infections caused by susceptible gram-negative bacteria, particularly Enterobacteriaceae. May also be used for other infections as determined by a healthcare provider based on susceptibility testing.
As a beta-lactam antibiotic, it inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan in the bacterial cell wall. Without a intact cell wall, bacteria cannot maintain structural integrity and eventually die.
Patients with known penicillin allergy should avoid this medication. Common side effects may include gastrointestinal symptoms such as nausea and diarrhea. Complete the full prescribed course even if symptoms improve to prevent antibiotic resistance. Always use under medical supervision with appropriate diagnostic confirmation of bacterial infection.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy