Amiloride / Atenolol / Hydrochlorothiazide
Amiloride/Atenolol/Hydrochlorothiazide is a combination medication used to treat high blood pressure (hypertension). It combines three drugs: a beta-blocker (atenolol), a thiazide diuretic (hydrochlorothiazide), and a potassium-sparing diuretic (amiloride). This multi-mechanism approach helps reduce blood pressure more effectively than single-agent therapy and is typically prescribed when single medications prove insufficient.
A three-drug combination for hypertension that combines a beta-blocker with two types of diuretics for enhanced blood pressure control.
Key facts at a glance
- RxNorm
- 153154
- Generic
- Amiloride / Atenolol / Hydrochlorothiazide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for the treatment of essential hypertension (high blood pressure) in patients who require multiple antihypertensive agents to achieve adequate blood pressure control.
Atenolol blocks beta-adrenergic receptors, reducing heart rate and cardiac output. Hydrochlorothiazide promotes fluid excretion through the kidneys, reducing blood volume. Amiloride works as a potassium-sparing diuretic to counteract the potassium-depleting effects of hydrochlorothiazide while contributing additional antihypertensive effect.
Regular monitoring of blood pressure, electrolytes (especially potassium), and kidney function is recommended. Patients should avoid potassium supplements or potassium-rich foods unless directed, as amiloride retains potassium. Common side effects may include dizziness, fatigue, and electrolyte imbalances. This combination may not be suitable for patients with certain heart conditions, severe kidney disease, or who are pregnant.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy