Amiloride / Bendroflumethiazide
Amiloride/Bendroflumethiazide is a combination diuretic medication used to treat high blood pressure and fluid retention (edema). The thiazide component (bendroflumethiazide) helps remove excess fluid and sodium, while the potassium-sparing component (amiloride) helps prevent potassium loss, making this combination useful when balancing fluid removal with electrolyte preservation.
A combination diuretic used to treat high blood pressure and fluid retention, designed to maximize fluid removal while preserving potassium levels.
Key facts at a glance
- RxNorm
- 1009137
- Generic
- Amiloride / Bendroflumethiazide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of essential hypertension and management of edema associated with heart failure, liver cirrhosis, and renal dysfunction. Often prescribed when single-diuretic therapy is insufficient for blood pressure or fluid control.
Bendroflumethiazide inhibits sodium reabsorption in the distal convoluted tubule, promoting urinary sodium and water excretion. Amiloride blocks sodium channels in the collecting duct, preventing potassium excretion and counteracting the potassium-depleting effects of the thiazide diuretic.
Monitor for hyperkalemia (high potassium), especially in patients with kidney problems or those taking other potassium-affecting medications. Avoid potassium supplements and salt substitutes containing potassium unless specifically directed. May cause dizziness; rise slowly from sitting or lying positions. Regular electrolyte monitoring is recommended during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy