Amiloride / Bumetanide
Amiloride/Bumetanide is a combination medication pairing a loop diuretic (Bumetanide) with a potassium-sparing diuretic (Amiloride). This combination promotes fluid removal while helping preserve potassium levels in the body, making it useful for patients requiring diuresis who are at risk for or already experiencing low potassium. The medication is typically used when single-agent diuretic therapy is insufficient.
A combination diuretic that removes excess fluid while helping maintain potassium levels.
Key facts at a glance
- RxNorm
- 645371
- Generic
- Amiloride / Bumetanide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats edema associated with heart failure, liver cirrhosis, and kidney disorders when additional diuresis beyond single-agent therapy is needed and potassium conservation is desirable.
Bumetanide inhibits sodium reabsorption in the thick ascending limb of the loop of Henle, causing strong diuresis, while Amiloride blocks sodium channels in the collecting duct to reduce potassium losses that typically accompany loop diuretics.
Monitor for electrolyte imbalances including both high and low potassium, dehydration, and kidney function. May cause dizziness; avoid alcohol. Contraindicated in patients with severe kidney impairment, Addison's disease, or hyperkalemia. Drug interactions with ACE inhibitors, ARBs, and NSAIDs require careful monitoring.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy