Amiloride / Cyclopenthiazide
Amiloride/Cyclopenthiazide is a combination diuretic medication used to treat high blood pressure and fluid retention (edema). Cyclopenthiazide helps remove excess fluid and sodium from the body, while amiloride prevents potassium loss, making this combination particularly useful when potassium conservation is important. This medication is typically prescribed when single-agent diuretic therapy is insufficient.
A combination diuretic that removes excess fluid while preserving potassium levels, used for hypertension and edema.
Key facts at a glance
- RxNorm
- 608649
- Generic
- Amiloride / Cyclopenthiazide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of essential hypertension and management of edema associated with heart failure, liver cirrhosis, and kidney disorders. Particularly useful when potassium conservation is desirable alongside fluid removal.
Cyclopenthiazide inhibits sodium reabsorption in the distal convoluted tubule, promoting water and sodium excretion. Amiloride blocks sodium channels in the collecting duct, reducing potassium secretion and providing a potassium-sparing effect that counteracts thiazide-induced hypokalemia.
Regular monitoring of electrolytes (especially potassium) and kidney function is essential. Contraindicated in hyperkalemia, severe renal impairment, and concurrent use with other potassium-sparing agents. May cause dizziness; avoid alcohol. Not recommended during pregnancy without careful benefit-risk assessment.
Official drug label
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy