Amiloride / Furosemide / Indapamide
This combination medication contains three diuretics (a potassium-sparing and two potassium-wasting) that work at different sites in the kidney to increase fluid and salt excretion. It is used when single-agent diuretic therapy is inadequate for controlling high blood pressure or reducing fluid retention (edema). The combination provides complementary mechanisms for more effective blood pressure control and fluid management.
A triple-combination diuretic used for hypertension and fluid retention, working at multiple sites in the kidney to enhance fluid and salt removal.
Key facts at a glance
- RxNorm
- 1009094
- Generic
- Amiloride / Furosemide / Indapamide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of essential hypertension and management of edema associated with heart failure, liver disease, or kidney disorders when single-agent diuretic therapy proves insufficient.
The three agents work synergistically: Amiloride blocks sodium channels in the collecting duct (potassium-sparing), Furosemide inhibits the Na-K-2Cl transporter in the loop of Henle, and Indapamide acts on the distal convoluted tubule. Together they enhance sodium and water excretion through complementary mechanisms.
Regular monitoring of electrolytes (especially potassium), kidney function, and blood pressure is essential. Dehydration and electrolyte imbalances are potential risks. Patients should avoid potassium supplements unless specifically directed. This combination may interact with other blood pressure medications, NSAIDs, and lithium. Not typically used as first-line therapy.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy