Amiloride / Hydrochlorothiazide
Amiloride/Hydrochlorothiazide is a combination diuretic medication used to treat high blood pressure and fluid retention (edema) associated with heart failure, liver disease, or kidney disorders. It combines two types of water pills: a thiazide diuretic that removes excess fluid and sodium, with a potassium-sparing agent that helps maintain normal potassium levels. This combination helps prevent the potassium loss commonly seen with thiazide diuretics alone.
A combination diuretic that treats high blood pressure and fluid retention while helping preserve potassium levels.
Key facts at a glance
- RxNorm
- 214212
- Generic
- Amiloride / Hydrochlorothiazide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of hypertension (high blood pressure) and management of edema associated with congestive heart failure, cirrhosis of the liver, and kidney disorders. Used when potassium depletion is a concern with thiazide therapy alone.
Hydrochlorothiazide inhibits sodium reabsorption in the kidney's distal tubule, promoting water and sodium excretion. Amiloride blocks sodium channels in the collecting duct, reducing sodium reabsorption while sparing potassium. Together, they provide additive diuretic effects while minimizing potassium loss.
May cause hyperkalemia (elevated potassium), especially in patients with kidney disease or those taking potassium supplements. Monitor kidney function and electrolytes regularly. Can increase blood sugar levels. Avoid in patients with anuria, severe kidney impairment, or hyperkalemia. May cause dizziness; use caution when rising from sitting or lying position.
Official drug label
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If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy