Amiloride / Hydrochlorothiazide / Timolol
This medication combines three antihypertensive agents—amiloride (potassium-sparing diuretic), hydrochlorothiazide (thiazide diuretic), and timolol (beta-blocker)—working through complementary mechanisms to lower blood pressure. It is typically prescribed for patients with hypertension who require multiple medications to achieve adequate blood pressure control.
A triple-combination antihypertensive medication used when single-agent therapy is insufficient for blood pressure control.
Key facts at a glance
- RxNorm
- 812786
- Generic
- Amiloride / Hydrochlorothiazide / Timolol
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of hypertension (high blood pressure) in patients who require combination therapy to achieve target blood pressure goals.
Hydrochlorothiazide reduces fluid volume by increasing urinary excretion of sodium and water; amiloride prevents potassium loss while also promoting sodium excretion; timolol reduces heart rate and cardiac output by blocking beta-adrenergic receptors. Together, they provide complementary blood pressure-lowering effects.
Requires monitoring of electrolyte levels (particularly potassium) and renal function. May cause dizziness; avoid alcohol and rising quickly from sitting/lying position. Inform physicians before surgery. Not recommended during pregnancy. May interact with other blood pressure medications, NSAIDs, and lithium.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy