Aminophylline / Ephedrine / Guaifenesin / Phenobarbital
This multi-ingredient medication combines bronchodilators (aminophylline and ephedrine) with an expectorant (guaifenesin) and a barbiturate sedative (phenobarbital). It is primarily used for respiratory conditions involving bronchospasm and excessive mucus production, such as asthma and emphysema. The combination works to open airways, loosen respiratory secretions, and reduce anxiety during breathing difficulties.
A respiratory medication combining bronchodilators, an expectorant, and a mild sedative for treatment of asthma and COPD symptoms.
Key facts at a glance
- RxNorm
- 690788
- Generic
- Aminophylline / Ephedrine / Guaifenesin / Phenobarbital
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of asthma, emphysema, chronic bronchitis, and other respiratory conditions characterized by bronchospasm, wheezing, and mucus congestion.
Aminophylline and ephedrine relax bronchial smooth muscles to widen airways; guaifenesin helps thin and loosen respiratory secretions; phenobarbital provides mild sedation to reduce anxiety associated with breathing difficulties.
Contains a barbiturate with potential for dependence; may cause CNS stimulation, insomnia, or paradoxical reactions. Use with caution in patients with cardiovascular disease, hypertension, or thyroid disorders. Avoid alcohol and other CNS depressants. May interact with multiple medications including beta-blockers, MAOIs, and other bronchodilators.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy