Aminophylline / Guaifenesin
Aminophylline/Guaifenesin is a combination medication that provides both bronchodilation and mucus clearance support. It is typically used to treat respiratory conditions such as asthma, chronic bronchitis, and emphysema where opening airways and reducing chest congestion are beneficial. The two active ingredients work together to make breathing easier and help clear excess phlegm.
This combination bronchodilator and expectorant helps relieve breathing difficulties and congestion associated with respiratory conditions.
Key facts at a glance
- RxNorm
- 214216
- Generic
- Aminophylline / Guaifenesin
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for symptomatic relief of respiratory conditions including asthma, chronic bronchitis, emphysema, and other conditions involving bronchospasm and excessive mucus production where both airway dilation and expectoration are needed.
Aminophylline is a methylxanthine derivative that relaxes bronchial smooth muscle and improves breathing capacity, while Guaifenesin acts as an expectorant to thin and loosen mucus in the airways, making it easier to cough out.
May interact with various medications including antibiotics, heart medications, and seizure drugs. Common side effects include nausea, headache, and insomnia. Caffeine should be limited as it can increase side effects. Patients should have blood levels monitored periodically and should not exceed prescribed doses.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy